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# Immunoglobulin therapy - Whole blood and components

## Essential information

Obligatory
  1. Must not donate if:
     1. After 1 January 1980, the donor has been treated with intravenous or subcutaneous human immunoglobulin.
     2. The donor has received multiple intramuscular injections of high dose immunoglobulin.
     3. Immunosuppressed.
  2. Donors with recovered immunodeficiency:

  Refer to a Designated Clinical Support Officer.

  3. If treated with intravenous or subcutaneous human immunoglobulin:

  See Transfusion

Discretionary
  1. If the intravenous or subcutaneous human immunoglobulin was given before 1980, accept.
  2. If given routine ante- or post-natal anti-D immunoglobulin only (even if received more than 1 dose), accept.
  3. If single dose prophylactic immunoglobulin has been given, accept.

## Supporting information

See if relevant
  - Hepatitis A
  - Hepatitis B
  - Immunodeficiency
  - Prion-associated diseases
  - Rabies
  - Tetanus
Additional information

  Immunoglobulin used before 1980 is unlikely to be affected by vCJD (a prion associated disease).

  Single dose intramuscular immunoglobulin is unlikely to pose a significant risk of transmitting vCJD.

  This entry reflects guidance from the former Committee on the Microbiological Safety of Blood Tissues and Organs of the Department of Health.

Reason for change:
  Link updated from 'Immunosuppression' to 'Immunodeficiency' in the 'See if Relevant' section.
Version details:

  WB-DSG Edition 203 Release 73 (07 October 2024)

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